A new way to fight against Alzheimer

Alzheimer Researchers have found that cefixime – an antibiotic used to treat gonorrhea and pneumonia – can be effective in suppressing the development of Alzheimer’s disease.

A new way to fight against Alzheimer

The symptoms of Alzheimer’s disease are difficult to distinguish from the common types of dementia. The distinguishing feature is the presence of amyloid beta plaques in the brain that spread as the disease progresses. Most experimental drugs break these tiles. But many neuroscientists believe that amyloid beta is a symptom, not a basic cause of Alzheimer’s. 

Professor Stephen Strittmatter from Yale University tries to develop signaling that activates the formation of amyloid beta plaque. By interfering with the interaction between the PrPC protein and beta amyloid, the development of Alzheimer’s disease can be prevented.

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Strittmatter’s team tested 2560 existing drugs and 10,000 other molecules for their potential to disrupt amyloid beta plaques. Cefixime, still present in medicine, turned out to be particularly effective. It turned out that cefixime does not act directly on amyloid beta plaques, but at room temperature it breaks up PrPC / beta amyloid interactions. 

Researchers at Yale University have developed more efficient versions of the polymer that are able to cross the blood-brain barrier. It not only prevents the development of dementia in mice, but even gives a place to repair the brain, which improves their ability to navigate the maze. 

For human clinical trials, it’s still a long way off, but cefixime can actually turn out to be a miracle cure for Alzheimer’s.

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